[1] Zhou Tong, Gu Wanjun, Ma Jianmin, Sun Xiao, et al. Site discrepancy of synonymous codon usagein SARS coronavirus and other viruses in Coronaviridae [J]. Journal of Southeast University (English Edition), 2005, 21 (2): 203-206. [doi:10.3969/j.issn.1003-7985.2005.02.017]

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Site discrepancy of synonymous codon usagein SARS coronavirus and other viruses in Coronaviridae()

SARS及其他几种冠状病毒密码子使用偏性的位点差异

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Journal of Southeast University (English Edition)[ISSN:1003-7985/CN:32-1325/N]

Volumn:

21

Issue:

2005 2

Page:

203-206

Research Field:

Biological Science and Medical Engineering

Publishing date:

2005-06-30

Info

Title:

Site discrepancy of synonymous codon usagein SARS coronavirus and other viruses in Coronaviridae

SARS及其他几种冠状病毒密码子使用偏性的位点差异

Author(s):

Zhou Tong, Gu Wanjun, Ma Jianmin, Sun Xiao, Lu Zuhong

Key Laboratory of Molecular and Bio-Molecular Electronics of Ministry of Education, Southeast University, Nanjing 210096, China

周童, 顾万君, 马建民, 孙啸, 陆祖宏

东南大学分子与生物分子电子学教育部重点实验室, 南京 210096

Keywords:

codon usage;  severe acute respiratory syndrome(SARS);  coronavirus;  gene expression;  site discrepancy

密码子使用偏性;  SARS;  冠状病毒;  基因表达;  位点差异

PACS:

Q617

DOI:

10.3969/j.issn.1003-7985.2005.02.017

Abstract:

The synonymous codon usage in the translational initiation and termination regions of genes of severe acute respiratory syndrome(SARS)coronavirus and five other viruses in Coronaviridae was systematically analyzed.The results indicate that most minor codons for these coronaviruses are preferentially used in the initial and terminal region.The minor codons preferentially used in the initial region are thought to have a negative effect on gene expression, which can be explained by the minor codon modulator hypothesis.It also indicates that the minor codons preferentially used in the terminal region may regulate the level of gene expression.The proposed results strongly imply that the minor codon modulator hypothesis can be applied to both some bacteria and some viruses.

分析了SARS冠状病毒以及其他5种冠状病毒基因编码起始区与终止区的密码子使用偏性.结果表明, 冠状病毒基因组的稀有密码子倾向于出现在编码起始区和终止区附近.起始区的这种倾向性对冠状病毒基因的表达具有负性调控作用, 可以用“稀有密码子调控假说”解释.终止区的这种倾向性表明, 这些出现在终止区的稀有密码子对基因的表达也有负性调节作用.研究结果同时暗示了“稀有密码子调控假说”不仅适用于细菌, 而且还适用于某些病毒基因组.

References:

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Memo

Memo:

Biographies: Zhou Tong(1977—), male, graduate;Lu Zuhong(corresponding author), male, doctor, professor, zhlu@seu.edu.cn.

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