|Table of Contents|

[1] Xie Li, Shu Qing, Deng Guozhe, et al. Application of polypyrrole nanofibers in the selective extraction ofmethotrexate and its polyglutamate metabolites from hospital effluents [J]. Journal of Southeast University (English Edition), 2022, 38 (3): 284-290. [doi:10.3969/j.issn.1003-7985.2022.03.010]
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Application of polypyrrole nanofibers in the selective extraction ofmethotrexate and its polyglutamate metabolites from hospital effluents()
聚吡咯纳米纤维在医院废水中甲氨蝶呤 及其聚谷氨酸代谢物选择性萃取的应用
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Journal of Southeast University (English Edition)[ISSN:1003-7985/CN:32-1325/N]

Volumn:
38
Issue:
2022 3
Page:
284-290
Research Field:
Chemistry and Chemical Engineering
Publishing date:
2022-09-20

Info

Title:
Application of polypyrrole nanofibers in the selective extraction ofmethotrexate and its polyglutamate metabolites from hospital effluents
聚吡咯纳米纤维在医院废水中甲氨蝶呤 及其聚谷氨酸代谢物选择性萃取的应用
Author(s):
Xie Li1;  2;  Shu Qing3;  Deng Guozhe1;  Li Da1;  Kang Xuejun1;  Ge Weihong3
1School of Biological Science and Medical Engineering, Southeast University, Nanjing 210018, China
2College of Animal Science and Food Engineering, Jinling Institute of Technology, Nanjing 210038, China
3Department of Pharmacy, Nanjing Drum Tower Hospital, Nanjing 210008, China
谢丽1;  2;  束庆3;  邓国哲1;  李达1;  康学军1;  葛卫红3
1东南大学生物科学与医学工程学院, 南京 210018; 2金陵科技学院动物科学与技术学院, 南京 210038; 3南京鼓楼医院药剂科, 南京 210008
Keywords:
polypyrrole nanofibers;  solid-phase extraction;  liquid chromatography-tandem mass spectrometry(LC-MS/MS);  hospital effluents;  determination
聚吡咯纳米纤维;  固相萃取;  液相色谱-质谱联用(LC-MS/MS);  医疗废水;  测定
PACS:
O657.72
DOI:
10.3969/j.issn.1003-7985.2022.03.010
Abstract:
A novel solid-phase extraction(SPE)strategy based on polypyrrole(Ppy)nanofibers was developed for the determination of trace methotrexate and its polyglutamate metabolites(MTXs)in hospital effluents. Ppy was coated on the surface of electrospun polystyrene nanofibers by in situ oxidative polymerization to form Ppy electrospun nanofibers. The mechanism of adsorption on MTXs was explored through static adsorption studies. The MTX contents, after extraction, were determined by liquid chromatography-tandem mass spectrometry analysis. Results show that the physical/chemical adsorption of targets occurs on the surface of Ppy nanofibers, which is most likely dominated by multiple adsorptions and heterogeneous adsorption sites. Ppy nanofibers exhibit satisfying extraction performance. The content of targets detected in medical wastewater samples ranges from 21 to 2 908 ng/L. The novel strategy based on Ppy nanofiber SPE can extract trace MTXs effectively, guarantee analytical accuracy, and circumvent the storage and transportation of water samples during on-site sampling operations.
为实现医疗废水中甲氨蝶呤及其聚谷氨酸代谢物(MTXs)的痕量检测, 基于聚吡咯(Ppy)纳米纤维提出了一种新的固相萃取前处理方法.采用原位氧化聚合法, 将Ppy包覆在电纺PS纳米纤维表面, 形成Ppy电纺纳米纤维.通过静态吸附研究, 探索其对于MTXs吸附的作用机制.萃取完成后采用液相色谱-质谱联用(LC-MS/MS)技术检测MTXs浓度.结果表明, 目标物可能在Ppy表面发生物理/化学的多次吸附, 且吸附位点不均匀.Ppy对于MTXs展现出优良的提取性能, 医疗废水样品中目标物检测浓度为21~2 908 ng/L.基于Ppy纳米纤维固相萃取的前处理方法能够有效萃取痕量MTXs, 保证研究分析精度, 可现场采样操作, 避免水样的储存和运输.

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Memo

Memo:
Biographies: Xie Li(1987—), female, Ph.D. candidate; Kang Xuejun(corresponding author), female, doctor, professor, xjkang@163.com.
Foundation item: The National Natural Science Foundation of China(No. 82173575).
Citation: Xie Li, Shu Qing, Deng Guozhe, et al. Application of polypyrrole nanofibers in the selective extraction of methotrexate and its polyglutamate metabolites from hospital effluents[J].Journal of Southeast University(English Edition), 2022, 38(3):284-290.DOI:10.3969/j.issn.1003-7985.2022.03.010.
Last Update: 2022-09-20