[1] Xie Li, Shu Qing, Deng Guozhe, et al. Application of polypyrrole nanofibers in the selective extraction ofmethotrexate and its polyglutamate metabolites from hospital effluents [J]. Journal of Southeast University (English Edition), 2022, 38 (3): 284-290. [doi:10.3969/j.issn.1003-7985.2022.03.010]

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Application of polypyrrole nanofibers in the selective extraction ofmethotrexate and its polyglutamate metabolites from hospital effluents()

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Journal of Southeast University (English Edition)[ISSN:1003-7985/CN:32-1325/N]

Volumn:

38

Issue:

2022 3

Page:

284-290

Research Field:

Chemistry and Chemical Engineering

Publishing date:

2022-09-20

Info

Title:

Application of polypyrrole nanofibers in the selective extraction ofmethotrexate and its polyglutamate metabolites from hospital effluents

Author(s):

Xie Li¹;  2;  Shu Qing³;  Deng Guozhe¹;  Li Da¹;  Kang Xuejun¹;  Ge Weihong³

¹School of Biological Science and Medical Engineering, Southeast University, Nanjing 210018, China
²College of Animal Science and Food Engineering, Jinling Institute of Technology, Nanjing 210038, China
³Department of Pharmacy, Nanjing Drum Tower Hospital, Nanjing 210008, China

Keywords:

polypyrrole nanofibers;  solid-phase extraction;  liquid chromatography-tandem mass spectrometry(LC-MS/MS);  hospital effluents;  determination

PACS:

O657.72

DOI:

10.3969/j.issn.1003-7985.2022.03.010

Abstract:

A novel solid-phase extraction(SPE)strategy based on polypyrrole(Ppy)nanofibers was developed for the determination of trace methotrexate and its polyglutamate metabolites(MTXs)in hospital effluents. Ppy was coated on the surface of electrospun polystyrene nanofibers by in situ oxidative polymerization to form Ppy electrospun nanofibers. The mechanism of adsorption on MTXs was explored through static adsorption studies. The MTX contents, after extraction, were determined by liquid chromatography-tandem mass spectrometry analysis. Results show that the physical/chemical adsorption of targets occurs on the surface of Ppy nanofibers, which is most likely dominated by multiple adsorptions and heterogeneous adsorption sites. Ppy nanofibers exhibit satisfying extraction performance. The content of targets detected in medical wastewater samples ranges from 21 to 2 908 ng/L. The novel strategy based on Ppy nanofiber SPE can extract trace MTXs effectively, guarantee analytical accuracy, and circumvent the storage and transportation of water samples during on-site sampling operations.

References:

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Memo

Memo:

Biographies: Xie Li(1987—), female, Ph.D. candidate; Kang Xuejun(corresponding author), female, doctor, professor, xjkang@163.com.
Foundation item: The National Natural Science Foundation of China(No. 82173575).
Citation: Xie Li, Shu Qing, Deng Guozhe, et al. Application of polypyrrole nanofibers in the selective extraction of methotrexate and its polyglutamate metabolites from hospital effluents[J].Journal of Southeast University(English Edition), 2022, 38(3):284-290.DOI:10.3969/j.issn.1003-7985.2022.03.010.

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