[1] Chen Ping, Yang Fang, Fang Kun, Gu Aiyuan, et al. A system for evaluationof ultrasound contrast agent’s enhancement effect [J]. Journal of Southeast University (English Edition), 2010, 26 (1): 82-86. [doi:10.3969/j.issn.1003-7985.2010.01017]

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A system for evaluationof ultrasound contrast agent’s enhancement effect()

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Journal of Southeast University (English Edition)[ISSN:1003-7985/CN:32-1325/N]

Volumn:

26

Issue:

2010 1

Page:

82-86

Research Field:

Biological Science and Medical Engineering

Publishing date:

2010-03-30

Info

Title:

A system for evaluationof ultrasound contrast agent’s enhancement effect

Author(s):

Chen Ping¹;  Yang Fang¹;  Fang Kun¹;  Gu Aiyuan²;  Qian Zhuoyu³;  Wang Peng⁴;  Gu Ning¹

¹Jiangsu Key Laboratory for Biomaterials and Devices, Southeast University, Nanjing 210096, China
²Belson Imaging Technology Co., Ltd., Wuxi 214092, China
³Imaging Science and Technology Laboratory, Southeast Unive

Keywords:

microbubble;  ultrasound phantom;  enhancement imaging;  optimal settings

PACS:

R445.1

DOI:

10.3969/j.issn.1003-7985.2010.01017

Abstract:

A system for in vitro investigation of ultrasound contrast agent’s enhancement effect is presented and evaluated. It includes the digital B-mode ultrasound scanner Belson3000A, the tissue-mimicking ultrasound phantoms and the software which is used for image quantitative analysis. The linear range, optimal settings and repeatability of the system are assessed and explored by scanning the ultrasound phantoms with different reflective intensities. The measurements are performed under an acoustic power from 4.8 to 12.3 mW, the scanner centre frequency is 3.5 MH and the gain setting is 50 dB. Both a self-made surfactant encapsulated microbubble and a commercial ultrasound contrast agent are scanned. The results show that the pixel intensity of ultrasonic images increases with the increase in the sound power, and for the stronger reflective phantoms of more particles, the increasing trend is much more evident. The system is optimal for evaluating the microbubble contrast agents’ enhancement effects. It presents a simple, effective and real-time means for characterizing the enhancement ability of microbubbles.

References:

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Memo

Memo:

Biographies: Chen Ping(1984—), female, graduate; Gu Ning(corresponding author), male, doctor, professor, guning@seu.edu.cn.
Foundation items: The National Basic Research Program of China(973 Program)(No.2006CB933206), the National Natural Science Foundation of China(No.50872021, 60725101).
Citation: Chen Ping, Yang Fang, Fang Kun, et al. A system for evaluation of ultrasound contrast agent’s enhancement effect[J]. Journal of Southeast University(English Edition), 2010, 26(1): 82-86.

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