[1] Shen Xiaoyan, Wang Zhigong, Lü Xiaoying, et al. Neural function rebuilding on different bodiesusing microelectronic neural bridge technique [J]. Journal of Southeast University (English Edition), 2010, 26 (4): 523-527. [doi:10.3969/j.issn.1003-7985.2010.04.004]

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Neural function rebuilding on different bodiesusing microelectronic neural bridge technique()

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Journal of Southeast University (English Edition)[ISSN:1003-7985/CN:32-1325/N]

Volumn:

26

Issue:

2010 4

Page:

523-527

Research Field:

Biological Science and Medical Engineering

Publishing date:

2010-12-30

Info

Title:

Neural function rebuilding on different bodiesusing microelectronic neural bridge technique

Author(s):

Shen Xiaoyan¹;  3;  Wang Zhigong¹;  Lü Xiaoying²;  Li Wenyuan¹;  Zhao Xintai¹;  Huang Zonghao¹

¹Institute of RF- & OE-ICs, Southeast University, Nanjing 210096, China
²State Key Laboratory of Bioelectronics, Southeast University, Nanjing 210096, China
³School of Electronic Information, Nantong University, Nantong 226019, China

Keywords:

neural function regeneration;  electromy-ography(EMG);  microelectronic neural bridge;  coherence function

PACS:

Q426

DOI:

10.3969/j.issn.1003-7985.2010.04.004

Abstract:

A microelectronic circuit is used to regenerate the neural signals between the proximal end and the distal end of an injured nerve. An experimental scheme is designed and carried out to verify the feasibility of the so-called microelectronic neural bridge(MNB). The sciatic signals of the source spinal toad which are evoked by chemical stimuli are used as source signals to stimulate the sciatic of the controlled spinal toad. The sciatic nerve signals of the source spinal toad, the regenerated sciatic signals in the controlled spinal toad, and the resulting electromyography(EMG)signals associated with the gastrocnemius muscle movements of the controlled spinal toad are displayed and recorded by an oscilloscope. By analyzing the coherence between the source sciatic nerve signals and the regenerated sciatic nerve signals and the coherence between the regenerated nerve signals and the EMG signals, it is proved that the regenerated sciatic nerve signals have a relationship with the source sciatic nerve signals and control shrinkage of the leg of the controlled toad.

References:

[1] Willerth S M, Sakiyama-Elbert S E. Cell therapy for spinal cord regeneration [J]. Advanced Drug Delivery Reviews, 2008, 60(2):263-276.
[2] Fujiwara Y, Tanaka N, Ishida O, et al. Intravenously injected neural progenitor cells of transgenic rats can migrate to the injured spinal cord and differentiate into neurons, astrocytes and oligodendrocytes [J]. Neuroscience Letters, 2004, 366(3):287-291.
[3] Hayashi K, Ohta S, Kawakami Y, et al. Activation of dendritic-like cells and neural stem/progenitor cells in injured spinal cord by GM-CSF [J]. Neuroscience Research, 2009, 64(1):96-103.
[4] Han S S W, Kang D Y, Mujtaba T, et al. Grafted lineage-restricted precursors differentiate exclusively into neurons in the adult spinal cord [J]. Experimental Neurology, 2002, 177(2):360-375.
[5] Ao Q, Wang A J, Chen G Q, et al. Combined transplantation of neural stem cells and olfactory ensheathing cells for the repair of spinal cord injuries [J]. Medical Hypotheses, 2007, 69(6):1234-1237.
[6] Wang Zhigong, Lü Xiaoying, Gu Xiaosong. Research of central nerve signal recording. processing and regeneration with microelectronics devices[C]//The 14th Conference on Neural Networks of China. Hefei, China, 2004:10-15.(in Chinese)
[7] Wang Zhigong, Gu Xiaosong, Lü Xiaoying. The method and equipment for neural channel bridge aided by a micro-electronic system: Chinese patent, 200510135541.6.[P]. 2008-12-24.
[8] Wang Zhigong, Lü Xiaoying, Li Wenyuan, et al. Study of microelectronics for detecting and stimulating of central neural signals [C]//Proceedings of the First International Conference on Neural Interface and Control. Wuhan, China, 2005: 192-195.
[9] Wang Yufeng, Wang Zhigong, Gu Xiaosong, et al. Fully integrated and low power CMOS amplifier for neural signal recording[C]//Proceedings of the 27th Annual International Conference of Engineering in Medicine and Biology Society. Shanghai, China, 2005: 5250-5253.
[10] Wang Yufeng, Wang Zhigong, Lü Xiaoying, et al. A single-chip and low-power CMOS amplifier for neural signal detection[J]. Chinese Journal of Semiconductors, 2006, 27(8): 1490-1495.
[11] Wang Zhigong, Gu Xiaosong, Lü Xiaoying, et al. Microelectronics-embedded channel bridging and signal regeneration of injured spinal cords [J]. Progress in Natural Science, 2009, 19(10):1261-1269.
[12] Huang Zonghao, Wang Zhigong, Lü Xiaoying, et al. Six-channel neural signal regeneration integrated circuit [C]//32nd Annual International Conference of the IEEE EMBS. Buenos Aires, Argentina, 2010: 1523-1526.
[13] Halliday D M, Conway B A, Farmer S F, et al. Using electroencephalography to study functional coupling between cortical activity and electromyograms during voluntary contractions in humans [J]. Neuroscience Letters, 1998, 241(1):5-8.
[14] Jia Yutao, Luo Zhizeng. Summary of EMG feature extraction[J].Chinese Journal of Electron Devices, 2007, 30(1): 326-330.
[15] Mima T, Hallett M. Electroencephalographic analysis of cortico-muscular coherence: reference effect, volume conduction and generator mechanism [J]. Clinical Neurophysiology, 1999, 110(11):1892-1899.
[16] Mima T, Steger J, Schulman A E, et al. Electroencephalographic measurement of motor cortex control of muscle activity in humans [J]. Clinical Neurophysiology, 2000, 111(2):326-337.
[17] Grosse P, Cassidy M J, Brown P. EEG-EMG, MEG-EMG and EMG-EMG frequency analysis: physiological principles and clinical applications [J]. Clinical Neurophysiology, 2002, 113(10):1523-1531.
[18] Yang Zhan, Halliday D, Jiang Ping, et al. Detecting time-dependent coherence between non-stationary electrophysiological signals—a combined statistical and time-frequency approach [J]. Journal of Neuroscience Methods, 2006, 156(1/2):322-332.
[19] Torrence C, Compo G P. A pratical guide to wavelet analysis[J]. Bull Am Meteo Soc, 1998, 9(1):61-78.

Memo

Memo:

Biographies: Shen Xiaoyan(1969—), female, doctor, associate professor; Wang Zhigong(corresponding author), male, doctor, professor, zgwang@seu.edu.cn.
Foundation items: The National Natural Science Foundation of China(No.90307013, 90707005), the Natural Science Foundation of Jiangsu Province(No.BK2008032), Special Foundation and Open Foundation of State Key Laboratory of Bioelectronics of Southeast University, Nantong Planning Project of Science and Technology(No. K2009037).
Citation: Shen Xiaoyan, Wang Zhigong, Lü Xiaoying, et al. Neural function rebuilding on different bodies using microelectronic neural bridge technique[J].Journal of Southeast University(English Edition), 2010, 26(4):523-527.

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