[1] Zhou Tong, Gu Wanjun, Ma Jianmin, Sun Xiao, et al. Site discrepancy of synonymous codon usagein SARS coronavirus and other viruses in Coronaviridae [J]. Journal of Southeast University (English Edition), 2005, 21 (2): 203-206. [doi:10.3969/j.issn.1003-7985.2005.02.017]

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Site discrepancy of synonymous codon usagein SARS coronavirus and other viruses in Coronaviridae()

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Journal of Southeast University (English Edition)[ISSN:1003-7985/CN:32-1325/N]

Volumn:

21

Issue:

2005 2

Page:

203-206

Research Field:

Biological Science and Medical Engineering

Publishing date:

2005-06-30

Info

Title:

Site discrepancy of synonymous codon usagein SARS coronavirus and other viruses in Coronaviridae

Author(s):

Zhou Tong;  Gu Wanjun;  Ma Jianmin;  Sun Xiao;  Lu Zuhong

Key Laboratory of Molecular and Bio-Molecular Electronics of Ministry of Education, Southeast University, Nanjing 210096, China

Keywords:

codon usage;  severe acute respiratory syndrome(SARS);  coronavirus;  gene expression;  site discrepancy

PACS:

Q617

DOI:

10.3969/j.issn.1003-7985.2005.02.017

Abstract:

The synonymous codon usage in the translational initiation and termination regions of genes of severe acute respiratory syndrome(SARS)coronavirus and five other viruses in Coronaviridae was systematically analyzed.The results indicate that most minor codons for these coronaviruses are preferentially used in the initial and terminal region.The minor codons preferentially used in the initial region are thought to have a negative effect on gene expression, which can be explained by the minor codon modulator hypothesis.It also indicates that the minor codons preferentially used in the terminal region may regulate the level of gene expression.The proposed results strongly imply that the minor codon modulator hypothesis can be applied to both some bacteria and some viruses.

References:

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Memo

Memo:

Biographies: Zhou Tong(1977—), male, graduate;Lu Zuhong(corresponding author), male, doctor, professor, zhlu@seu.edu.cn.

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