[1] Li Wenyuan, Wang Zhigong, Lü Xiaoying, Gu Xiaosong, et al. Multi-channel neural signal stimulating moduleand in-vivo experiments [J]. Journal of Southeast University (English Edition), 2007, 23 (1): 26-30. [doi:10.3969/j.issn.1003-7985.2007.01.006]

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Multi-channel neural signal stimulating moduleand in-vivo experiments()

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Journal of Southeast University (English Edition)[ISSN:1003-7985/CN:32-1325/N]

Volumn:

23

Issue:

2007 1

Page:

26-30

Research Field:

Biological Science and Medical Engineering

Publishing date:

2007-03-30

Info

Title:

Multi-channel neural signal stimulating moduleand in-vivo experiments

Author(s):

Li Wenyuan¹;  Wang Zhigong¹;  Lü Xiaoying²;  Gu Xiaosong³;  Zhang Zhenyu¹

¹Institute of RF- & OE-ICs, Southeast University, Nanjing 210096, China
²State Key Laboratory of Bioelectronics, Southeast University, Nanjing 210096, China
³Key Laboratory of Neural Regeneration of Jiangsu Province, Nantong University, Nantong 226001, China

Keywords:

microelectrode;  neural function regeneration;  function electrical stimulation;  neural signal channel;  stimulation

PACS:

R318;TP274

DOI:

10.3969/j.issn.1003-7985.2007.01.006

Abstract:

The module for function electrical stimulation(FES)of neurons is designed for the research of the neural function regeneration microelectronic system, which is an in-body embedded micro module. It is implemented by using discrete devices at first and characterized in vitro. The module is used to stimulate sciatic nerve and spinal cord of rats and rabbits for in-vivo real-time experiments of the neural function regeneration system. Based on the module, a four channel module for the FES of neurons is designed for 12 sites cuff electrode or 10 sites shaft electrode. Three animal experiments with total five rats and two rabbits were made. In the in-vivo experiment, the neural signals including spontaneous and imitated were regenerated by the module. The stimulating signal was used to drive sciatic nerve and spinal cord of rats and rabbits, successfully caused them twitch in different parts of their bodies, such as legs, tails, and fingers. This testifies that the neural function regeneration system can regenerate the neural signals.

References:

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[2] Wang Zhigong, Lü Xiaoying, Li Wenyuan, et al.Study of microelectronics for detecting and stimulating of central neural signals [C]//Proceedings of International Conference on Neural Interface and Control. Wuhan, China, 2005:192-200.
[3] Li Wenyuan, Zhang Zhenyu, Wang Zhigong.Function electrical stimulation signals generator circuits for the central nerve and the sciatic nerve [C]// Proceedings of the 2005 IEEE Engineering in Medicine and Biology.Shanghai, China, 2005:5287-5290.
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[8] Andreasen Lotte N S, Struijk Johannes J.Skin contact forces extracted from human nerve signals—a possible feedback signal for FES-aided control of standing [J].IEEE Transactions on Biomedical Engineering, 2003, 50(12):1320-1326.
[9] Demosthenous Andreas, Taylor John, Triantis Iasonas F, et al.Design of an adaptive interference reduction system for nerve-cuff electrode recordings [J].IEEE Transactions on Circuits and Systems-Ⅰ, 2004, 51(4):629-639.
[10] Harb A, Hu Y, Sawan M, et al.Low-power CMOS interface for recording and processing very low amplitude signals [J].Analog Integrated Circuits and Signal Processing, 2004, 39(1):39-54.
[11] Elokda Ahmed S, Nielsen David H, Shields Richard K.Effect of functional neuromuscular stimulation on postural related orthostatic stress in individuals with acute spinal cord injury [J].Journal of Rehabilitation Research & Development, 2000, 37(5):535-542.
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Memo

Memo:

Biography: Li Wenyuan(1964—), male, associate professor, lwy555@seu.edu.cn.

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