[1] Ge Yuhua, Sun Hui, Wang Mingliang,. Crystal structure and fluorescence property of antofloxacin [J]. Journal of Southeast University (English Edition), 2011, 27 (4): 449-451. [doi:10.3969/j.issn.1003-7985.2011.04.020]

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Crystal structure and fluorescence property of antofloxacin()

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Journal of Southeast University (English Edition)[ISSN:1003-7985/CN:32-1325/N]

Volumn:

27

Issue:

2011 4

Page:

449-451

Research Field:

Mathematics, Physics, Mechanics

Publishing date:

2011-12-31

Info

Title:

Crystal structure and fluorescence property of antofloxacin

Author(s):

Ge Yuhua;  Sun Hui;  Wang Mingliang

School of Chemistry and Chemical Engineering, Southeast University, Nanjing 211189, China

Keywords:

antofloxacin;  flouroquinolones;  crystal structure;  fluorescence property

PACS:

O723

DOI:

10.3969/j.issn.1003-7985.2011.04.020

Abstract:

Antofloxacin free base is prepared from antofloxacin hydrochloride by removing hydrogen chloride. Its crystal is obtained by slow evaporation of an acetonitrile-methanol mixed solution. Single-crystal X-ray diffraction reveals that the crystallography belongs to a triclinic P1- space group with cell parameters: a=0.66307(13)nm, b=0.89839(18)nm, c=1.5690(3)nm, α=75.12(3)°, β=87.92(3)°, γ=77.57(3)°. Antofloxacin shows no fluorescence in solution, but the crystalline state emits strong green light at 510 nm under the excitation of 360 nm, indicating a fluorescence enhancement induced by aggregation. It demonstrates that intermolecular packing and interaction in the crystal lead to the improved fluorescence quantum yield. These results provide important information for the further exploration of the structure-activity relationship of antofloxacin and the development of new drugs.

References:

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Memo

Memo:

Biography: Ge Yuhua(1966—), male, doctor, associate professor, Geyuhua@263.net.
Citation: Ge Yuhua, Sun Hui, Wang Mingliang. Crystal structure and fluorescence property of antofloxacin[J].Journal of Southeast University(English Edition), 2011, 27(4):449-451.[doi:10.3969/j.issn.1003-7985.2011.04.020]

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