|Table of Contents|

[1] Zhang Haiqian, *, Shinohara Hiroaki, Gu Ning, et al. Cell Adhesion Inhibition by RGD Peptides Linkedwith a Photoisomerizable Nonnatural Amino Acid [J]. Journal of Southeast University (English Edition), 2001, 17 (2): 22-26. [doi:10.3969/j.issn.1003-7985.2001.02.006]
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Cell Adhesion Inhibition by RGD Peptides Linkedwith a Photoisomerizable Nonnatural Amino Acid()
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Journal of Southeast University (English Edition)[ISSN:1003-7985/CN:32-1325/N]

Volumn:
17
Issue:
2001 2
Page:
22-26
Research Field:
Biological Science and Medical Engineering
Publishing date:
2001-12-30

Info

Title:
Cell Adhesion Inhibition by RGD Peptides Linkedwith a Photoisomerizable Nonnatural Amino Acid
Author(s):
Zhang Haiqian1 2* Shinohara Hiroaki2 Gu Ning1 Sasaki Hiroshi2 Sisido Masahiko2
1Laboratory of Wu Chien-shiung, Southeast University, Nanjing 210096, China
2Department of Bioscience and Biotechnology, Faculty of Engineering, Okayama University, Okayama 700-8530, Japan
Keywords:
nonnatural amino acid cell adhesion photoisomerization integrin peptide
PACS:
Q517;Q518.4
DOI:
10.3969/j.issn.1003-7985.2001.02.006
Abstract:
RGD peptides linked with a nonnatural amino acid, phenylazophenyl alaninine(azoAla), were synthesized and applied to cell adhesion inhibitors. The RGD peptides linked with azoAla at C-terminal showed potent binding to the integrin on the surface of HeLa cells. Photoisomerization effect of the azobenzene side chain of synthesized peptides on the cell adhesion inhibition was further investigated. It was demonstrated that the cis-form of azoAla-linked RGD peptides revealed a little weak cell adhesion inhibition effect as compared with trans-form of azoAla-linked RGD peptide.

References:

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Memo

Memo:
* Born in 1963, male, associate professor, doctor.
Last Update: 2001-06-20