[1] Xu Haiqing, Jiang Lijian, Zhang Zhenglin, Wei Benmei, et al. New method for preparation of D-valine [J]. Journal of Southeast University (English Edition), 2004, 20 (1): 59-61. [doi:10.3969/j.issn.1003-7985.2004.01.012]
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New method for preparation of D-valine(
)
)Journal of Southeast University (English Edition)[ISSN:1003-7985/CN:32-1325/N]
- Volumn:
- 20
- Issue:
- 2004 1
- Page:
- 59-61
- Research Field:
- Chemistry and Chemical Engineering
- Publishing date:
- 2004-03-30
Info
- Title:
- New method for preparation of D-valine
- Author(s):
- Xu Haiqing; Jiang Lijian; Zhang Zhenglin; Wei Benmei
- Department of Chemistry and Chemical Engineering, Southeast University, Nanjing 210096, China
- Keywords:
- L-valine; racemization; chemical resolution; D-valine
- PACS:
- O629.71
- DOI:
- 10.3969/j.issn.1003-7985.2004.01.012
- Abstract:
- A method for preparing D-valine from L-valine by racemization and chemical resolution is presented. The resolving reagent, D-2, 3-dibenzoyl tartaric acid was obtained by hydrolyzation of D-2, 3-dibenzoyl tartaric anhydride prepared by reaction of benzoyl chloride with D-tartaric acid. DL-valine was prepared by racemization of L-valine in the presence of aldehyde in a medium of acetic acid at 100 to 110 ℃ for 3 h. In the presence of mineral acid, reaction of D-2, 3-dibenzoyl tartaric acid with DL-valine formed diastreroisomeric salts at 84 to 95 ℃. Salt composed of D-2, 3-dibenzoyl tartaric acid and D-valine precipitated when the diastreroisomeric salts mixtures were cooled to 15 ℃. The salt was reacted with base giving D-valine with yield of 70% to 80% and optical purity of over 98%.
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Memo
- Memo:
- Biographies: Xu Haiqing(1974—), male, graduate; Jiang Lijian(corresponding author), male, doctor, professor, ljjiang@jlonline.com.