[1] Li Yunhui, Zhou Jue, Zhang Minhui, Yang MingLi Xiaobo, et al. Effects of microcystin-LR on hippocampal N-acetylaspartateand neurobehaviors in rats [J]. Journal of Southeast University (English Edition), 2015, 31 (4): 577-581. [doi:10.3969/j.issn.1003-7985.2015.04.025]

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Effects of microcystin-LR on hippocampal N-acetylaspartateand neurobehaviors in rats()

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Journal of Southeast University (English Edition)[ISSN:1003-7985/CN:32-1325/N]

Volumn:

31

Issue:

2015 4

Page:

577-581

Research Field:

Biological Science and Medical Engineering

Publishing date:

2015-12-30

Info

Title:

Effects of microcystin-LR on hippocampal N-acetylaspartateand neurobehaviors in rats

Author(s):

Li Yunhui¹;  Zhou Jue¹;  Zhang Minhui¹;  Yang Ming²Li Xiaobo¹;  Liu Ran¹;  Yin Lihong¹;  Pu Yuepu¹

¹Key Laboratory of Environmental Medicine Engineering of Ministry of Education, Southeast University, Nanjing 210009, China
²Jiangsu Key Laboratory of Molecule Imaging and Functional Imaging, Southeast University, Nanjing 210009, China

Keywords:

low-doses of microcystin-leucine-arginine(MC-LR);  N-acetylaspartate(NAA);  neurobeha-viors;  magnetic resonance spectroscopy;  neuro

PACS:

R12

DOI:

10.3969/j.issn.1003-7985.2015.04.025

Abstract:

The effects of low-doses of microcystin-leucine-arginine(MC-LR)exposure on neurobehaviors and N-acetylaspartate(NAA)expression in the hippocampus of rats were investigated. After male Sprague-Dawley(SD)rats were treated intra-gastrically with different doses of MC-LR for 90 d, the locomotor activity, spatial learning and memory function were evaluated in the rats after treatment using open field tests and Morris water maze tests. The results show that MC-LR exposure can lead to impairment of the spatial learning capacity and locomotor activity in rats at the dose of 2.00 μg/kg. The levels of NAA in the hippocampus were measured by magnetic resonance spectroscopy(MRI). A significant decrease of NAA/Cr ratio(P<0.05)was observed in the hippocampous. This study indicates that intra-gastrical exposure to low-doses of MC-LR has adverse effects on neuronal behavior and NAA levels in the hippocampous.

References:

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Memo

Memo:

Biography: Li Yunhui(1968—), male, doctor, associate professor, yhli@seu.edu.cn.
Foundation item: The National Natural Science Foundation of China(No.81072258, 81273123).
Citation: Li Yunhui, Zhou Jue, Zhang Minhui, et al. Effects of microcystin-LR on hippocampal N-acetylaspartate and neurobehaviors in rats[J].Journal of Southeast University(English Edition), 2015, 31(4):577-581.[doi:10.3969/j.issn.1003-7985.2015.04.025]

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