|Table of Contents|

[1] Wu Gensheng, Zhang Yin, Si Wei, Gu Yunfeng, et al. Current blockade mechanism for DNA translocationthrough solid-state nanopore with different membrane thickness [J]. Journal of Southeast University (English Edition), 2016, 32 (3): 301-306. [doi:10.3969/j.issn.1003-7985.2016.03.007]
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Current blockade mechanism for DNA translocationthrough solid-state nanopore with different membrane thickness()
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Journal of Southeast University (English Edition)[ISSN:1003-7985/CN:32-1325/N]

Volumn:
32
Issue:
2016 3
Page:
301-306
Research Field:
Mathematics, Physics, Mechanics
Publishing date:
2016-09-20

Info

Title:
Current blockade mechanism for DNA translocationthrough solid-state nanopore with different membrane thickness
Author(s):
Wu Gensheng1;  Zhang Yin2;  Si Wei2;  Gu Yunfeng1;  Chen Yunfei2
1School of Mechanical and Electronic Engineering, Nanjing Forestry University, Nanjing 210037, China
2Jiangsu Key Laboratory for Design and Manufacture of Micro-Nano Biomedical Instruments, Southeast University, Nanjing 211189, China
Keywords:
nanopore;  DNA sequencing;  relative current blockade;  membrane thickness
PACS:
O561.4
DOI:
10.3969/j.issn.1003-7985.2016.03.007
Abstract:
The current blockade mechanism for λ-DNA translocation under electrical field is investigated through solid-state nanopores with different pore thicknesses. The conductance of a nanopore system mainly consists of the contribution of the pore and access region, and the latter becomes dominant when the nanopore thickness gradually decreases to atomic layer thickness. Based on the existing model of nanopore resistance, a simplified model which describes the relative current blockade during the λ-DNA translocation through the nanopores is deduced to quantitatively present the relationship between nanopore thickness and relative current blockade. Results show that the relative current blockade is effectively increased by reducing the nanopore diameter but it decreases with the decreasing nanopore thickness. A two-stage schematic is proposed to increase the relative current blockade by setting a much smaller resistance region. Experimental results show a 21.9% increase in the relative current blockade with the proposed schematic.

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Memo

Memo:
Biography: Wu Gensheng(1986—), male, doctor, lecturer, genshengwu@126.com.
Foundation items: The Natural Science Foundation of Jiangsu Province(No.BK20160935), the Natural Science Foundation of Higher Education Institutions of Jiangsu Province(No.16KJB460015).
Citation: Wu Gensheng, Zhang Yin, Si Wei, et al.Current blockade mechanism for DNA translocation through solid-state nanopore with different membrane thickness[J].Journal of Southeast University(English Edition), 2016, 32(3):301-306.DOI:10.3969/j.issn.1003-7985.2016.03.007.
Last Update: 2016-09-20