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[1] Dai Lin, Zhang Yong, Hu Chi, Qian Hongliang, et al. Mathematical modeling for ultrasonic-assisted extractionof arctigenin from acid hydrolyzed FructusArctii [J]. Journal of Southeast University (English Edition), 2017, 33 (3): 362-369. [doi:10.3969/j.issn.1003-7985.2017.03.017]
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Mathematical modeling for ultrasonic-assisted extractionof arctigenin from acid hydrolyzed FructusArctii()
超声提取牛蒡子酸水解产物中牛蒡苷元的数学模型
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Journal of Southeast University (English Edition)[ISSN:1003-7985/CN:32-1325/N]

Volumn:
33
Issue:
2017 3
Page:
362-369
Research Field:
Biological Science and Medical Engineering
Publishing date:
2017-09-30

Info

Title:
Mathematical modeling for ultrasonic-assisted extractionof arctigenin from acid hydrolyzed FructusArctii
超声提取牛蒡子酸水解产物中牛蒡苷元的数学模型
Author(s):
Dai Lin, Zhang Yong, Hu Chi, Qian Hongliang, Wang Zhixiang
School of Engineering, China Pharmaceutical University, Nanjing 210009, China
戴琳, 张勇, 胡驰, 钱红亮, 王志祥
中国药科大学工学院, 南京210009
Keywords:
FructusArctii acid hydrolysis ultrasonic-assisted extraction arctigenin mathematical model
牛蒡子 酸水解 超声提取 牛蒡苷元 数学模型
PACS:
R93
DOI:
10.3969/j.issn.1003-7985.2017.03.017
Abstract:
A mathematical model based on Fick’s first law was established to describe the process of ultrasonic-assisted extraction of arctigenin from acid hydrolyzed FructusArctii. Acid hydrolization with hydrochloric acid promotes the conversion of arctiin to arctigenin in the arctiin-rich active pharmaceutical ingredient, and the hydrolyzed products were further examined to investigate the process setup. By considering the mechanism of the extraction process and experimental data, the effects of parameters including solvent to solid ratio, particle size of hydrolyzed samples, ethanol volume fraction, ultrasound power, extraction temperature and extraction time on concentration of arctigenin were analyzed in detail. The model was suitable for simulating the process of ultrasonic-assisted extraction of arctigenin. The simulation results of the model agree well with experimental data with the deviation below 13%, indicating that the mathematical model can provide valuable guidance for the extraction of arctigenin from acid hydrolyzed FructusArctii.
基于Fick第一定律对超声提取牛蒡子酸水解产物中牛蒡苷元的过程建立了数学模型及其求解方法.采用盐酸对牛蒡子原药材进行酸水解, 促使药材中含量较高的牛蒡子苷转化为苷元, 然后以酸水解产物为原料, 研究超声提取牛蒡苷元的工艺条件.在超声提取单元素实验中, 着重考察了温度、时间、超声功率、乙醇浓度、液固比、原料粒径、占空比和提取溶剂8个因素对牛蒡苷元提取率及浸膏纯度的影响.将模拟结果与实验值进行比较, 结果表明模型的计算值与实验值之间存在一定的误差, 误差低于13%, 但各因素对提取效果的影响规律与实验结果基本一致.

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Memo

Memo:
Biographies: Dai Lin(1981—), male, master, lecturer; Wang Zhixiang(corresponding author), male, doctor, professor, 1443590147@qq.com.
Foundation items: The National Natural Science Foundation of China(No.21406272, 21676291), the Fundamental Research Funds for the Central Universities(No.2632017ZD01), Jiangsu Planned Projects for Postdoctoral Research Funds(No.1402060B).
Citation: Dai Lin, Zhang Yong, Hu Chi, et al. Mathematical modeling for ultrasonic-assisted extraction of arctigenin from acid hydrolyzed FructusArctii[J].Journal of Southeast University(English Edition), 2017, 33(3):362-369.DOI:10.3969/j.issn.1003-7985.2017.03.017.
Last Update: 2017-09-20