[1] Yang Li, , Ma Yinhang, et al. In situ nanobubble sizing by visualization particle trackingand image-based dynamic light scattering [J]. Journal of Southeast University (English Edition), 2021, 37 (3): 237-244. [doi:10.3969/j.issn.1003-7985.2021.03.001]

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In situ nanobubble sizing by visualization particle trackingand image-based dynamic light scattering()

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Journal of Southeast University (English Edition)[ISSN:1003-7985/CN:32-1325/N]

Volumn:

37

Issue:

2021 3

Page:

237-244

Research Field:

Mathematics, Physics, Mechanics

Publishing date:

2021-09-20

Info

Title:

In situ nanobubble sizing by visualization particle trackingand image-based dynamic light scattering

Author(s):

Yang Li¹;  2;  3;  Ma Yinhang⁴;  Jin Juan¹;  2;  3;  Yang Fujun⁴;  Yang Fang¹;  2;  3;  Huang Bin¹;  2;  3;  Li Yan¹;  2;  3;  Gu Ning¹;  2;  3

¹School of Biological Science and Medical Engineering, Southeast University, Nanjing 210096, China
²State Key Laboratory of Bioelectronics, Southeast University, Nanjing 210096, China
³Jiangsu Key Laboratory for Biomaterials and Devices, Southeast University, Nanjing 210096, China
⁴ School of Civil Engineering, Southeast University, Nanjing 210096, China

Keywords:

real-time acquisition;  nanobubble(NB)sizing;  visualization particle tracking;  image dynamic light scattering;  Brownian motion

PACS:

O433.1

DOI:

10.3969/j.issn.1003-7985.2021.03.001

Abstract:

A novel method combining visualization particle tracking with image-based dynamic light scattering was developed to achieve the in situ and real-time size measurement of nanobubbles(NBs). First, the in situ size distribution of NBs was visualized by dark-field microscopy. Then, real-time size during the preparation was measured using image-based dynamic light scattering, and the longitudinal size distribution of NBs in the sample cell was obtained in a steady state. Results show that this strategy can provide a detailed and accurate size of bubbles in the whole sample compared with the commercial ZetaSizer Nano equipment. Therefore, the developed method is a real-time and simple technology with excellent accuracy, providing new insights into the accurate measurement of the size distribution of NBs or nanoparticles in solution.

References:

[1] Duan L, Yang L, Jin J, et al. Micro/nano-bubble-assisted ultrasound to enhance the EPR effect and potential theranostic applications[J]. Theranostics, 2020, 10(2): 462-483. DOI:10.7150/thno.37593.
[2] Agarwal A, Ng W J, Liu Y. Principle and applications of microbubble and nanobubble technology for water treatment[J]. Chemosphere, 2011, 84(9): 1175-1180. DOI:10.1016/j.chemosphere.2011.05.054.
[3] Li M X, Liu Y, Chen J P, et al. Platelet bio-nanobubbles as microvascular recanalization nanoformulation for acute ischemic stroke lesion theranostics[J]. Theranostics, 2018, 8(18): 4870-4883. DOI:10.7150/thno.27466.
[4] Cavalli R, Bisazza A, Rolfo A, et al. Ultrasound-mediated oxygen delivery from chitosan nanobubbles[J]. International Journal of Pharmaceutics, 2009, 378(1/2): 215-217. DOI:10.1016/j.ijpharm.2009.05.058.
[5] Yin T H, Wang P, Zheng R Q, et al. Nanobubbles for enhanced ultrasound imaging of tumors[J]. International Journal of Nanomedicine, 2012, 7: 895-904. DOI:10.2147/IJN.S28830.
[6] Güvener N, Appold L, de Lorenzi F, et al. Recent advances in ultrasound-based diagnosis and therapy with micro- and nanometer-sized formulations[J]. Methods, 2017, 130: 4-13. DOI:10.1016/j.ymeth.2017.05.018.
[7] Yang F, Li Y X, Chen Z P, et al.Superparamagnetic iron oxide nanoparticle-embedded encapsulated microbubbles as dual contrast agents of magnetic resonance and ultrasound imaging[J]. Biomaterials, 2009, 30(23/24): 3882-3890. DOI:10.1016/j.biomaterials.2009.03.051.
[8] Yu X, Felicia P. Optimization of cavitation venturi tube design for pico and nano bubbles generation [J]. International Journal of Mining Science and Technology, 2015, 25(4): 523-529.DOI: 10.1016/j.ijmst.2015.05.002.
[9] Xu R. Light scattering: A review of particle characterization applications [J]. Particuology, 2015, 18: 11-21.DOI: 10.1016/j.partic.2014.05.002.
[10] Stetefeld J, McKenna S A, Patel T R. Dynamic light scattering: A practical guide and applications in biomedical sciences[J]. Biophysical Reviews, 2016, 8(4): 409-427. DOI:10.1007/s12551-016-0218-6.
[11] Salari A, Gnyawali V, Griffiths I M, et al. Shrinking microbubbles with microfluidics: Mathematical modelling to control microbubble sizes[J]. Soft Matter, 2017, 13(46): 8796-8806. DOI:10.1039/C7SM01418J.
[12] Sarkar K, Katiyar A, Jain P. Growth and dissolution of an encapsulated contrast microbubble: Effects of encapsulation permeability[J]. Ultrasound in Medicine & Biology, 2009, 35(8): 1385-1396. DOI:10.1016/j.ultrasmedbio.2009.04.010.
[13] Jing C, Gu Z, Ying Y L, et al. Chrominance to dimension: A real-time method for measuring the size of single gold nanoparticles[J]. Analytical Chemistry, 2012, 84(10): 4284-4291. DOI:10.1021/ac203118g.
[14] Bhandari P, Wang X L, Irudayaraj J. Oxygen nanobubble tracking by light scattering in single cells and tissues[J]. ACS Nano, 2017, 11(3): 2682-2688. DOI:10.1021/acsnano.6b07478.
[15] Jin J, Wang R, Tang J, et al. Dynamic tracking of bulk nanobubbles from microbubbles shrinkage to collapse [J]. Colloids and Surfaces A: Physicochemical and Engineering Aspects, 2020, 589: 124430. DOI: 10.1016/j.colsurfa.2020.124430.
[16] Xu C Z, Cai X S, Zhang J, et al. Fast nanoparticle sizing by image dynamic light scattering[J]. Particuology, 2015, 19: 82-85.
[17] Zhou W, Zhang J, Liu LL, et al. Ultrafast image-based dynamic light scattering for nanoparticle sizing[J]. The Review of Scientific Instruments, 2015, 86(11): 115107. DOI:10.1063/1.4935503.
[18] Frisken B J. Revisiting the method of cumulants for the analysis of dynamic light-scattering data[J]. Applied Optics, 2001, 40(24): 4087-4091. DOI:10.1364/ao.40.004087.
[19] Koppel D E. Analysis of macromolecularpolydispersity in intensity correlation spectroscopy: The method of cumulants[J]. The Journal of Chemical Physics, 1972, 57(11): 4814-4820. DOI:10.1063/1.1678153.
[20] Jin J, Feng Z Q, Yang F, et al. Bulk nanobubbles fabricated by repeated compression of microbubbles[J]. Langmuir, 2019, 35(12): 4238-4245. DOI:10.1021/acs.langmuir.8b04314.
[21] Fu X W, Chen B, Tang J, et al.Photoinduced nanobubble-driven superfast diffusion of nanoparticles imaged by 4D electron microscopy[J]. Science Advances, 2017, 3(8): e1701160. DOI:10.1126/sciadv.1701160.
[22] Mailer A G, Clegg P S, Pusey P N. Particle sizing by dynamic light scattering: Non-linear cumulant analysis[J]. Journal of Physics Condensed Matter, 2015, 27(14): 145102. DOI:10.1088/0953-8984/27/14/145102.
[23] Hassan P A, Kulshreshtha S K. Modification to the cumulant analysis of polydispersity in quasielastic light scattering data[J]. Journal of Colloid and Interface Science, 2006, 300(2): 744-748. DOI:10.1016/j.jcis.2006.04.013.

Memo

Memo:

Biographies: Yang Li(1986—), female, Ph.D. candidate; Gu Ning(corresponding author), male, doctor, professor, guning@seu.edu.cn.
Foundation items: The National Key Research and Development Program of China(No. 2017YFA0104302), the National Natural Science Foundation of China(No. 51832001, 61821002, 81971750).
Citation: Yang Li, Ma Yinhang, Jin Juan, et al.In situ nanobubble sizing by visualization particle tracking and image-based dynamic light scattering[J].Journal of Southeast University(English Edition), 2021, 37(3):237-244.DOI:10.3969/j.issn.1003-7985.2021.03.001.

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