[1] Zhang Haiqian, *, Shinohara Hiroaki, Gu Ning, et al. Cell Adhesion Inhibition by RGD Peptides Linkedwith a Photoisomerizable Nonnatural Amino Acid [J]. Journal of Southeast University (English Edition), 2001, 17 (2): 22-26. [doi:10.3969/j.issn.1003-7985.2001.02.006]

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Cell Adhesion Inhibition by RGD Peptides Linkedwith a Photoisomerizable Nonnatural Amino Acid()

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Journal of Southeast University (English Edition)[ISSN:1003-7985/CN:32-1325/N]

Volumn:

17

Issue:

2001 2

Page:

22-26

Research Field:

Biological Science and Medical Engineering

Publishing date:

2001-12-30

Info

Title:

Cell Adhesion Inhibition by RGD Peptides Linkedwith a Photoisomerizable Nonnatural Amino Acid

Author(s):

Zhang Haiqian¹;  2*;  Shinohara Hiroaki²;  Gu Ning¹;  Sasaki Hiroshi²;  Sisido Masahiko²

¹Laboratory of Wu Chien-shiung, Southeast University, Nanjing 210096, China
²Department of Bioscience and Biotechnology, Faculty of Engineering, Okayama University, Okayama 700-8530, Japan

Keywords:

nonnatural amino acid;  cell adhesion;  photoisomerization;  integrin;  peptide

PACS:

Q517;Q518.4

DOI:

10.3969/j.issn.1003-7985.2001.02.006

Abstract:

RGD peptides linked with a nonnatural amino acid, phenylazophenyl alaninine(azoAla), were synthesized and applied to cell adhesion inhibitors. The RGD peptides linked with azoAla at C-terminal showed potent binding to the integrin on the surface of HeLa cells. Photoisomerization effect of the azobenzene side chain of synthesized peptides on the cell adhesion inhibition was further investigated. It was demonstrated that the cis-form of azoAla-linked RGD peptides revealed a little weak cell adhesion inhibition effect as compared with trans-form of azoAla-linked RGD peptide.

References:

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Memo

Memo:

* Born in 1963, male, associate professor, doctor.

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