[1] Qin Yurong, Jiang Yuehua, Lai Shengli,. Analytical model for power dissipation in cell membranesin suspensions exposed to electric fields [J]. Journal of Southeast University (English Edition), 2005, 21 (2): 145-148. [doi:10.3969/j.issn.1003-7985.2005.02.006]

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Analytical model for power dissipation in cell membranesin suspensions exposed to electric fields()

外电场作用下悬液中细胞膜损耗功率计算模型

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Journal of Southeast University (English Edition)[ISSN:1003-7985/CN:32-1325/N]

Volumn:

21

Issue:

2005 2

Page:

145-148

Research Field:

Biological Science and Medical Engineering

Publishing date:

2005-06-30

Info

Title:

Analytical model for power dissipation in cell membranesin suspensions exposed to electric fields

外电场作用下悬液中细胞膜损耗功率计算模型

Author(s):

Qin Yurong¹;  Jiang Yuehua²;  Lai Shengli¹

¹College of Electronic and Information Engineering, South China University of Technology, Guangzhou 510640, China
² Department of Medical Research, General Hospital of Guangzhou Military Command, Guangzhou 510010, China

覃玉荣¹;  江悦华²;  赖声礼¹

¹华南理工大学电子与信息信学院, 广州 510640; ²广州军区广州总医院医学实验科, 广州 510010

Keywords:

power dissipation;  analytical model;  cell suspension;  external electric fields

损耗功率;  计算模型;  细胞悬液;  外加电场

PACS:

R815

DOI:

10.3969/j.issn.1003-7985.2005.02.006

Abstract:

Due to interaction among cells, it is too complex to build an exact analytical model for the power dissipation within the cell membrane in suspensions exposed to external fields.An approximate equivalence method is proposed to resolve this problem.Based on the effective medium theory, the transmembrane voltage on cells in suspensions was investigated by the equivalence principle.Then the electric field in the cell membrane was determined.Finally, analytical solutions for the power dissipation within the cell membrane in suspensions exposed to external fields were derived according to the Joule principle.The equations show that the conductive power dissipation is predominant within the cell membrane in suspensions exposed to direct current or lower frequencies, and dielectric power dissipation prevails at high frequencies exceeding the relaxation frequency of the exposed membrane.

由于细胞间相互作用的复杂性使得建立外电场作用下悬液细胞膜损耗功率计算模型非常困难, 提出了用场近似等效方法解决该建模难题.基于有效介质理论, 用等效原理, 研究了外电场作用下悬液细胞跨膜电压变化规律, 然后确定细胞膜内电场分布.最后根据焦耳定律, 建立了外电场作用下悬液细胞膜损耗功率计算模型.模型表明:对直流和低频场, 悬液细胞膜的能量损耗主要为导电损耗;当外加频率超过细胞膜的弛豫频率时, 介质损耗占主导部分.

References:

[1] Kotnik T, Miklavcic D.Theoretical evalution of the distributed power dissipation in biological cells exposed to electric fields [J].Bioelectromagnetics, 2000, 21(5):385-394.
[2] Pavlin M, Slivnik T, Miklavcic D.Effective conductivity of cell suspensions [J].IEEE Transactions on Biomedical Engineering, 2002, 49(1):77-80.
[3] Qin Y R, Lai S L.Analytical model for transmembrane voltage induced on a cell membrane in suspensions [J].Journal of Southeast University(Natural Science Edition), 2004, 34(5):661-664.
[4] Raicu V, Saibara T, Enzan H, et al.Dielectric properties of rat liver in vivo:analysis by modeling hepatocytes in the tissue architecture [J].Bioelectrochemistry and Bioenergetics, 1998, 47(2):333-342.
[5] Grosse C, Schwan H P.Cellular membrane potentials induced by alternating fields [J].Biophys J, 1992, 63(6):1632-1642.

Memo

Memo:

Biographies: Qin Yurong(1965—), female, graduate;Lai Shengli(corresponding author), male, professor, soka@263.net.

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