[1] Xie Shushan, Wang Zhigong, Pan Haixian, Lü Xiaoying, et al. Neuronal signal detecting and stimulating circuit arrayfor monolithic integrated MEA [J]. Journal of Southeast University (English Edition), 2009, 25 (2): 175-179. [doi:10.3969/j.issn.1003-7985.2009.02.007]

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Neuronal signal detecting and stimulating circuit arrayfor monolithic integrated MEA()

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Journal of Southeast University (English Edition)[ISSN:1003-7985/CN:32-1325/N]

Volumn:

25

Issue:

2009 2

Page:

175-179

Research Field:

Electronic Science and Engineering

Publishing date:

2009-06-30

Info

Title:

Neuronal signal detecting and stimulating circuit arrayfor monolithic integrated MEA

Author(s):

Xie Shushan¹;  Wang Zhigong¹;  Pan Haixian²;  Lü Xiaoying²

¹ Institute of RF- & OE-ICs, Southeast University, Nanjing 210096, China
² State Key Laboratory of Bio-Electronics, Southeast University, Nanjing 210096, China

Keywords:

neuronal signal;  detecting;  noise;  micro-electrode array(MEA);  complementary metal-oxide-semiconductor transistor(CMOS)technology

PACS:

TN722.7;Q421

DOI:

10.3969/j.issn.1003-7985.2009.02.007

Abstract:

A neuronal signal detecting circuit and a neuronal signal stimulating circuit designed for a monolithic integrated MEA(micro-electrode array)system are described.As a basic cell of the circuits, an OPA(operational amplifier)is designed with low power, low noise, small size and high gain.The detecting circuit has a chip area of 290 μm×400 μm, a power dissipation of 2.02 mW, an equivalent input noise of 17.72 nV/Hz, a gain of 60.5 dB, and an output voltage from -2.48 to+2.5 V.The stimulating circuit has a chip area of 130 μm×290 μm, a power dissipation of 740 μW, and an output voltage from-2.5 to 2.04 V.The parameters show that two circuits are suitable for a monolithic integrated MEA system.The detecting circuit and MEA have been fabricated.The test results show that the detecting circuit works well.

References:

[1] Wang Zhigong, Lü Xiaoying, Gu Xiaosong.Research of central nerve signal recording, processing and regeneration with microelectronics devices[C]//The 14th Conference on Neural Networks of China. Hefei, China, 2004:10-15.(in Chinese)
[2] Wang Zhigong, Lü Xiaoying, Li Wenyuan, et al.Study of microelectronics for detecting and stimulating of central neural signals[C]//Proceedings of IEEE International Conference on Neural Interface and Control.Wuhan, China, 2005:192-200.
[3] Eversmann B, Jenkner M, Hofmann F, et al.A 128×128 CMOS biosensor array for extracellular recording of neural activity[J].IEEE J Solid-State Circuits, 2003, 38(12):2306-2317.
[4] Heer F, Hafizovic S, Franks W, et al.CMOS microelectrode array for bidirectional interaction with neuronal networks[J].IEEE J Solid-State Circuits, 2006, 41(7):1620-1629.
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[7] Lee T H.The design of CMOS radio-frequency integrated circuits[M].Cambridge, England:Cambridge University Press, 2004:348-363.
[8] Li Wenyuan, Wang Zhigong.Integrated circuit for single channel neural signal regeneration[J].Journal of Southeast University:English Edition, 2008, 24(2):155-158.
[9] Harrison R R, Charles C.A low-power low-noise CMOS amplifier for neural recording application[J].IEEE J Solid-State Circuits, 2003, 38(6):958-965.
[10] Wang Yufeng, Wang Zhigong, Lü Xiaoying, et al.A multichannel neural signal detecting module:its design and test in animal expriments[J].Progress in Nature Science, 2007, 17(6):675-680.
[11] Wang Yufeng, Wang Zhigong, Gu Xiaosong, et al.Fully integrated and low power CMOS amplifier for neural signal recording[C]//Proceedings of the 27th Annual International Conference of Engineering in Medicine and Biology Society.Shanghai, China, 2005:5250-5253.
[12] Nielsen J H, Lehmann T.An implantable CMOS amplifier for nerve signals[C]//The 8th IEEE International Conference on Electronics, Circuits and Systems.Malta, 2001, 3:1183-1186.

Memo

Memo:

Biographies: Xie Shushan(1981—), male, graduate;Wang Zhigong(corresponding author), male, doctor, professor, zgwang@seu.edu.cn.
Foundation items: The National Natural Science Foundation of China(No.90307013, 90707005), the Natural Science Foundation of Jiangsu Province(No.BK2008032), Open Foundation of State Key Laboratory of Bio-Electronics of Southeast University.
Citation: Xie Shushan, Wang Zhigong, Pan Haixian, et al.Neuronal signal detecting and stimulating circuit array for monolithic integrated MEA[J].Journal of Southeast University(English Edition), 2009, 25(2):175-179.

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