[1] Li Wenyuan, Wang Zhigong,. Integrated circuit for single channel neural signal regeneration [J]. Journal of Southeast University (English Edition), 2008, 24 (2): 155-158. [doi:10.3969/j.issn.1003-7985.2008.02.006]
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Integrated circuit for single channel neural signal regeneration(
)
单通道神经信号再生集成电路
)Journal of Southeast University (English Edition)[ISSN:1003-7985/CN:32-1325/N]
- Volumn:
- 24
- Issue:
- 2008 2
- Page:
- 155-158
- Research Field:
- Electronic Science and Engineering
- Publishing date:
- 2008-06-03
Info
- Title:
- Integrated circuit for single channel neural signal regeneration
- 单通道神经信号再生集成电路
- Author(s):
- Li Wenyuan; Wang Zhigong
- Institute of RF- & OE-ICs, Southeast University, Nanjing 210096, China
- Keywords:
- neural signal regeneration; function electrical stimulation; integrated circuit; electrode; CMOS technology
- PACS:
- TN722;Q424
- DOI:
- 10.3969/j.issn.1003-7985.2008.02.006
- Abstract:
- Based on the 4-channel neural signal regeneration system which is realized by using discrete devices and successfully used for in-vivo experiments on rats and rabbits, a single channel neural signal regeneration integrated circuit(IC)is designed and realized in CSMC’s 0.6 μm CMOS(complementary metal-oxide-semiconductor transistor)technology.The IC consists of a neural signal detection circuit with an adjustable gain, a buffer, and a function electrical stimulation(FES)circuit.The neural signal regenerating IC occupies a die area of 1.42 mm×1.34 mm.Under a dual supply voltage of ±2.5 V, the DC power consumption is less than 10 mW.The on-wafer measurement results are as follows:the output resistor is 118 mΩ, the 3 dB bandwidth is greater than 30 kHz, and the gain can be variable from 50 to 90 dB.The circuit is used for in-vivo experiments on the rat’s sciatic nerve as well as on the spinal cord with the cuff type electrode array and the twin-needle electrode.The neural signal is successfully regenerated both on a rat’s sciatic nerve bundle and on the spinal cord.
- 将利用分立器件设计的4通道神经信号再生电子系统成功地应用于大鼠和家兔的活体动物实验, 再生了它们的神经信号.采用相同的原理, 用CSMC 0.6 μm CMOS工艺设计实现了单通道神经信号再生集成电路.电路由增益可调的神经信号探测电路、缓冲器和神经功能电激励电路构成.电路采用±2.5 V双电源电压供电.芯片尺寸为1.42 mm×1.34 mm.在片测试电路的静态功耗小于10 mW, 输出电阻为118 mΩ, 3 dB带宽大于30 kHz, 增益在50~90 dB可调.电路芯片与卡肤电极、针状双体电极一起, 用于大鼠的神经信号再生的活体动物实验, 成功地再生了大鼠的坐骨神经和脊髓神经信号.
References:
[1] Wang Zhigong, Lü Xiaoying, Gu Xiaosong, et al.Microelectronic detecting, processing and rebuilding of central neural signals[C]//The Third Joint Symposium on Opto- and MicroElectronic Devices and Circuits. Wuhan, China, 2004:22-26.
[2] Wang Zhigong, Lü Xiaoying, Li Wenyuan, et al.Study of microelectronics for detecting and stimulating of central neural signals[C]//IEEE Proceedings of International Conference on Neural Interface and Control. Wuhan, China, 2005:192-200.
[3] Li Wenyuan, Wang Zhigong, Lü Xiaoying, et al.Multi-channel neural signal stimulating module and in-vivo experiments [J].Journal of Southeast University:English Edition, 2007, 23(1):26-30.
[4] Wang Yufeng, Wang Zhigong, Lü Xiaoying, et al.A multichannel neural signal detecting module:its design and test in animal experiments [J].Progress in Natural Science, 2007, 17(6):675-680.
[5] Wang Yufeng, Wang Zhigong, Lü Xiaoying, et al.Fully integrated and low power CMOS amplifier for neural signal recording[C]//Proceedings of the 2005 IEEE Engineering in Medicine and Biology. Shanghai, China, 2005:306.
[6] Li Wenyuan, Wang Zhigong, Zhang Zhenyu.Low-power CMOS IC for function electrical stimulation of nerves[J].Chinese Journal of Semiconductors, 2007, 28(3):393-397.
[7] Li Wenyuan, Zhang Zhenyu, Wang Zhigong.Function electrical stimulation signals generator circuits for the central nerve and the sciatic nerve[C]//Proceedings of the 2005 IEEE Engineering in Medicine and Biology 27th Annual Conference. Shanghai, China, 2005:282.
[8] Zhang Zhenyu, Li Wenyuan, Wang Zhigong.Circuit design for function electrical stimulation of central nerve system [J].Journal of Electrical and Electronic Education, 2005, l27(5):45-48.(in Chinese)
Memo
- Memo:
-
Biography: Li Wenyuan(1964—), male, associate professor, lwy555@seu.edu.cn.
Foundation item: The National Natural Science Foundation of China(No.90307013, 90707005).
Citation: Li Wenyuan, Wang Zhigong.Integrated circuit for single channel neural signal regeneration[J].Journal of Southeast University(English Edition), 2008, 24(2):155-158.