[1] Li Wenyuan, Wang Zhigong,. Integrated circuit for single channel neural signal regeneration [J]. Journal of Southeast University (English Edition), 2008, 24 (2): 155-158. [doi:10.3969/j.issn.1003-7985.2008.02.006]

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Integrated circuit for single channel neural signal regeneration()

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Journal of Southeast University (English Edition)[ISSN:1003-7985/CN:32-1325/N]

Volumn:

24

Issue:

2008 2

Page:

155-158

Research Field:

Electronic Science and Engineering

Publishing date:

2008-06-03

Info

Title:

Integrated circuit for single channel neural signal regeneration

Author(s):

Li Wenyuan;  Wang Zhigong

Institute of RF- & OE-ICs, Southeast University, Nanjing 210096, China

Keywords:

neural signal regeneration;  function electrical stimulation;  integrated circuit;  electrode;  CMOS technology

PACS:

TN722;Q424

DOI:

10.3969/j.issn.1003-7985.2008.02.006

Abstract:

Based on the 4-channel neural signal regeneration system which is realized by using discrete devices and successfully used for in-vivo experiments on rats and rabbits, a single channel neural signal regeneration integrated circuit(IC)is designed and realized in CSMC’s 0.6 μm CMOS(complementary metal-oxide-semiconductor transistor)technology.The IC consists of a neural signal detection circuit with an adjustable gain, a buffer, and a function electrical stimulation(FES)circuit.The neural signal regenerating IC occupies a die area of 1.42 mm×1.34 mm.Under a dual supply voltage of ±2.5 V, the DC power consumption is less than 10 mW.The on-wafer measurement results are as follows:the output resistor is 118 mΩ, the 3 dB bandwidth is greater than 30 kHz, and the gain can be variable from 50 to 90 dB.The circuit is used for in-vivo experiments on the rat’s sciatic nerve as well as on the spinal cord with the cuff type electrode array and the twin-needle electrode.The neural signal is successfully regenerated both on a rat’s sciatic nerve bundle and on the spinal cord.

References:

[1] Wang Zhigong, Lü Xiaoying, Gu Xiaosong, et al.Microelectronic detecting, processing and rebuilding of central neural signals[C]//The Third Joint Symposium on Opto- and MicroElectronic Devices and Circuits. Wuhan, China, 2004:22-26.
[2] Wang Zhigong, Lü Xiaoying, Li Wenyuan, et al.Study of microelectronics for detecting and stimulating of central neural signals[C]//IEEE Proceedings of International Conference on Neural Interface and Control. Wuhan, China, 2005:192-200.
[3] Li Wenyuan, Wang Zhigong, Lü Xiaoying, et al.Multi-channel neural signal stimulating module and in-vivo experiments [J].Journal of Southeast University:English Edition, 2007, 23(1):26-30.
[4] Wang Yufeng, Wang Zhigong, Lü Xiaoying, et al.A multichannel neural signal detecting module:its design and test in animal experiments [J].Progress in Natural Science, 2007, 17(6):675-680.
[5] Wang Yufeng, Wang Zhigong, Lü Xiaoying, et al.Fully integrated and low power CMOS amplifier for neural signal recording[C]//Proceedings of the 2005 IEEE Engineering in Medicine and Biology. Shanghai, China, 2005:306.
[6] Li Wenyuan, Wang Zhigong, Zhang Zhenyu.Low-power CMOS IC for function electrical stimulation of nerves[J].Chinese Journal of Semiconductors, 2007, 28(3):393-397.
[7] Li Wenyuan, Zhang Zhenyu, Wang Zhigong.Function electrical stimulation signals generator circuits for the central nerve and the sciatic nerve[C]//Proceedings of the 2005 IEEE Engineering in Medicine and Biology 27th Annual Conference. Shanghai, China, 2005:282.
[8] Zhang Zhenyu, Li Wenyuan, Wang Zhigong.Circuit design for function electrical stimulation of central nerve system [J].Journal of Electrical and Electronic Education, 2005, l27(5):45-48.(in Chinese)

Memo

Memo:

Biography: Li Wenyuan(1964—), male, associate professor, lwy555@seu.edu.cn.
Foundation item: The National Natural Science Foundation of China(No.90307013, 90707005).
Citation: Li Wenyuan, Wang Zhigong.Integrated circuit for single channel neural signal regeneration[J].Journal of Southeast University(English Edition), 2008, 24(2):155-158.

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