[1] Yang Xinan, Sun Xiao, Lu Zuhong,. Meta-analysis gene lists about subtypes of leukemiabased on gene expression data [J]. Journal of Southeast University (English Edition), 2006, 22 (2): 248-255. [doi:10.3969/j.issn.1003-7985.2006.02.022]
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Meta-analysis gene lists about subtypes of leukemiabased on gene expression data(
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)Journal of Southeast University (English Edition)[ISSN:1003-7985/CN:32-1325/N]
- Volumn:
- 22
- Issue:
- 2006 2
- Page:
- 248-255
- Research Field:
- Mathematics, Physics, Mechanics
- Publishing date:
- 2006-06-30
Info
- Title:
- Meta-analysis gene lists about subtypes of leukemiabased on gene expression data
- Author(s):
- Yang Xinan; Sun Xiao; Lu Zuhong
- State Key Laboratory of Bioelectronics, Southeast University, Nanjing 210096, China
- Keywords:
- oligonucleotide microarray; meta-analysis; rank score; leukemia
- PACS:
- O29;Q354
- DOI:
- 10.3969/j.issn.1003-7985.2006.02.022
- Abstract:
- To screen for molecular signatures that are commonly dysregulated in subtypes of a certain cancer, a novel meta-analysis is designed to perform rank score(RS)on lists of genes that are derived from different studies.RS is a promising way to detect signatures across platforms when integrating with one vs.all(OVA)or one vs.one(OVO)schemes of comparison.Among six published microarray expression datasets on acute leukemia, the biological signals hereafter provide stronger clustering support than systematic differences among microarray platforms.Moreover, the pediatric BCR-ABL specific genes can be used to correctly discriminate independent adult BCR-ABL cases.The obtained results redound to discover, validate and treat the subtypes from microarray gene expression profiles of cancer, which have been plentifully researched, such as leukemia.
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Memo
- Memo:
- Biographies: Yang Xinan(1971—), female, graduate;Lu Zuhong(corresponding author), male, doctor, professor, zhlu@seu.edu.cn.